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Endotoxins, also called LPS, are the component of the outer membrane of gram-negative bacteria and are released into the circulation upon disruption of the intact bacteria (death, cell lysis). Endotoxin is commonly found everywhere in our environment, and it is the most significant pyrogen in parenteral drugs and medical devices.

Endotoxins are also present in the digestive system. Their presence in the blood stream may cause septic reactions with a variety of symptoms such as fever, hypotension, nausea, shivering and shock. High concentrations can lead to serious complications such as disseminated intravascular coagulation (DIC), endotoxin shock and adult respiratory distress syndrome (ARDS). Endotoxins are known to activate complement, the kinin system, leukocytes, platelets and endothelial cells and are the “enemy” of both in vitro and in vivo study of blood–material interactions. In vivo, they may lead to the complications mentioned above, while in vitro, the presence of this contaminant may affect the results and compromise the conclusions.

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ELISA Plate kit
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INTENDED USE

The EndoAlert® ES Plate Kit is a kinetic, colorimetric assay for the quantitative determination of bacterial endotoxin in aqueous solutions.
The ES products are specifically formulated to detect and react only with endotoxin and are unreactive with (1,3) B-D glucans which are cell wall components of fungi.
Horseshoe crabs are harvested in a sustainable manner in compliance with the Atlantic States Marine Fisheries Commission.


MATERIALS PROVIDED IN THE ENDOALERT ES PLATE KIT

3 Vials    Chromogenic Lysate                                            Lyophilized
1 Vial      Endotoxin Specific Reconstitution Buffer      3.5 mL
1 Vial      Endotoxin Standard 10 EU/vial                         Lyophilized
1 Bottle  LAL Reagent Water (LRW)                                 10 mL
1 Piece   96-Well Microtiter Plate

ELISA Plate kit
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INTENDED USE

The EndoAlert Plate Kit is a kinetic, colorimetric assay for the quantitative determination of bacterial Endotoxin in aqueous solutions. Endotoxin, a bacterial lipopolysaccharide, is one of the major cell wall components of most gram-negative bacteria. The EndoAlert Plate Kit detects low levels of Endotoxin and is therefore a useful tool to assess the integrity of biological and environmental samples. The detection ranges from 0.01 – 10 Endotoxin units (EU/mL).

 

MATERIALS PROVIDED IN THE ENDOALERT PLATE KIT

3 Vials     Chromogenic Lysate                         Lyophilized
1 Vial       Endotoxin Standard 10 EU/vial      Lyophilized
1 Bottle   LAL Reagent Water (LRW)              10 ml
1 Piece    96-Well Microtiter Plate

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