The hand-held device incorporates a lab-on-a-chip module with interdigitated capacitive biosensing elements for label-free detection of multiple biomarkers.
Developed prototype that is comprised of a cartridge incorporating capacitive detection sensors, sensitive capacitive readout electronics enclosed in a hand-held unit, and data analysis software calculating the concentration of biomarkers using a previously stored reference database.
The capacitive detection sensors are made of interdigitated circular electrodes, which are preactivated with single (for detecting one biomarker) or multiple specific antibodies (for detecting multiple disease biomarkers).
The detection principle of capacitive biosensing devices is based on measuring the level of capacitance change between interdigitated electrode pairs induced by the change in dielectric constant due to affinity-based electron exchange between antibodies/antigens and electrodes. The more antibody-antigens binding occurs, the more capacitance change is measured due to the change in the dielectric constant of the capacitance media.
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Dr. Cohen
Dr. Cohen
Dr. Cohen
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